Outdoor transmission may represent fewer than one in 1000 Covid-19 cases. A database of more than 2000 international superspreader events found only one that happened exclusively outdoors.

Researchers examining the beginning of the outbreak in China looked at more than 7000 infections and found only one case of outdoor transmission. Strangely enough, few superspreader events have happened on aeroplanes or in gyms, likely due to better ventilation.

Source: What we've learned about the virus over 18 months in the wilderness

Higher production of infection-enhancing antibodies was found in patients with severe COVID-19. It was also found that non-infected individuals may have small amounts of infection-enhancing antibodies.

Antibodies that enhance SARS-CoV-2 infection

In the 10 years or so since the widespread use of B-cell depletion, there is little to suggest that a long-term paucity of B cells puts patients at risk for malignancy or opportunistic infections

And that was only 2020 😊

Many in the scientific community have felt comfortable in the knowledge that mRNA-based vaccines can be quickly modified and redeployed. If the our current vaccines fail, we revaccinate individuals with obsolete immunity against the new strains, and play global whack-a-mole as the virus evolves...

But it may not be that easy